DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
Howard Hughes Medical Institute · Johns Hopkins University · +5 more institutions
Abstract
Pancreatic neuroendocrine tumors (PanNETs) are a rare but clinically important form of pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic sequences of 10 nonfamilial PanNETs and then screened the most commonly mutated genes in 58 additional PanNETs. The most frequently mutated genes specify proteins implicated in chromatin remodeling: 44% of the tumors had somatic inactivating mutations in MEN1, which encodes menin, a component of a histone methyltransferase complex, and 43% had mutations in genes encoding either of the two subunits of a transcription/chromatin remodeling complex consisting of DAXX (death-domain-associated protein) and ATRX (α thalassemia/mental retardation…
Citation impact
- FWCI
- 85.93
- Percentile
- 100%
- References
- 28
Authors
16- YJYuchen JiaoCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Sidney Kimmel Cancer Center
- CSChanjuan ShiCorresponding
Johns Hopkins University, Cancer Research Center
- BHBarish H. Edil
Johns Hopkins University
- RFRoeland F. de Wilde
Johns Hopkins University, Cancer Research Center
- DSDavid S. Klimstra
Memorial Sloan Kettering Cancer Center
Topics & keywords
- ATRX
- Death-associated protein 6
- MEN1
- Neuroendocrine tumors
- PI3K/AKT/mTOR pathway
- Cancer research
- Biology
- Gene
- Good health and well-being