Oxidative Stress Resistance in Deinococcus radiodurans
Délégation Paris 5 · Inserm · +2 more institutions
Abstract
Deinococcus radiodurans is a robust bacterium best known for its capacity to repair massive DNA damage efficiently and accurately. It is extremely resistant to many DNA-damaging agents, including ionizing radiation and UV radiation (100 to 295 nm), desiccation, and mitomycin C, which induce oxidative damage not only to DNA but also to all cellular macromolecules via the production of reactive oxygen species. The extreme resilience of D. radiodurans to oxidative stress is imparted synergistically by an efficient protection of proteins against oxidative stress and an efficient DNA repair mechanism, enhanced by functional redundancies in both systems. D. radiodurans assets for the prevention of and recovery from…
Citation impact
- FWCI
- 16.23
- Percentile
- 100%
- References
- 700
Authors
2Topics & keywords
- Deinococcus radiodurans
- Oxidative stress
- DNA damage
- DNA repair
- Biology
- Reactive oxygen species
- Oxidative phosphorylation
- DNA