articlePhysics in Medicine and BiologyFeb 15, 2006Closed access

The modified Beer–Lambert law revisited

LKLászló KocsisPHPéter HermánAEAndrás Eke

Semmelweis University

PubMed
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Abstract

The modified Beer-Lambert law (MBLL) is the basis of continuous-wave near-infrared tissue spectroscopy (cwNIRS). The differential form of MBLL (dMBLL) states that the change in light attenuation is proportional to the changes in the concentrations of tissue chromophores, mainly oxy- and deoxyhaemoglobin. If attenuation changes are measured at two or more wavelengths, concentration changes can be calculated. The dMBLL is based on two assumptions: (1) the absorption of the tissue changes homogeneously, and (2) the scattering loss is constant. It is known that absorption changes are usually inhomogeneous, and therefore dMBLL underestimates the changes in concentrations (partial volume effect) and every calculated…

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Topics & keywords

Topics
Keywords
  • Attenuation coefficient
  • Attenuation
  • Chromophore
  • Scattering
  • Absorption (acoustics)
  • Wavelength
  • Beer–Lambert law
  • Materials science
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