Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus
University of California, San Francisco · Neurological Surgery · +2 more institutions
Abstract
New neurons continue to be born in the subgranular zone (SGZ) of the dentate gyrus in the hippocampus of adult mammals, including humans. Previous work has shown that astrocytes function as the progenitors of these new neurons through immature intermediate D cells. In the first part of the present study, we determined the structure of each of these progenitors and how they are organized in three dimensions. Serial-section reconstructions of the SGZ, using confocal and electron microscopy demonstrate that SGZ astrocytes form baskets that hold clusters of D cells, largely insulating them from the hilus. Two types of glial fibrillary acidic protein-expressing astrocytes (radial and horizontal) and three classes…
Citation impact
- FWCI
- 14.43
- Percentile
- 100%
- References
- 87
Authors
5- BSBettina Seri
University of California, San Francisco, Neurological Surgery, Rockefeller University
- JMJosé Manuel García‐Verdugo
Rockefeller University
- LCLucía Collado-Morente
Rockefeller University
- BSBruce S. McEwen
University of California, San Francisco, Neurological Surgery
- AÁArturo Álvarez-BuyllaCorresponding
Universitat de València
Topics & keywords
- Subgranular zone
- Dentate gyrus
- Biology
- Neurogenesis
- Progenitor cell
- Neuroscience
- Granule cell
- Glial fibrillary acidic protein