The structure of the human mitochondrial ribosome
MRC Laboratory of Molecular Biology · Medical Research Council
Abstract
The highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13 essential proteins of oxidative phosphorylation complexes. We have determined the structure of the intact mitoribosome to 3.5 angstrom resolution by means of single-particle electron cryogenic microscopy. It reveals 80 extensively interconnected proteins, 36 of which are specific to mitochondria, and three ribosomal RNA molecules. The head domain of the small subunit, particularly the messenger (mRNA) channel, is highly remodeled. Many intersubunit bridges are specific to the mitoribosome, which adopts conformations involving ratcheting or rolling of the small subunit that are distinct from those seen in bacteria or eukaryotes.…
Citation impact
- FWCI
- 23.94
- Percentile
- 100%
- References
- 63
Authors
5- AAAlexey AmuntsCorresponding
MRC Laboratory of Molecular Biology, Medical Research Council
- ABAlan BrownCorresponding
MRC Laboratory of Molecular Biology, Medical Research Council
- JTJaan Toots
MRC Laboratory of Molecular Biology, Medical Research Council
- SHSjors H. W. Scheres
MRC Laboratory of Molecular Biology, Medical Research Council
- VRV. RamakrishnanCorresponding
MRC Laboratory of Molecular Biology, Medical Research Council
Topics & keywords
- Mitochondrion
- Mitochondrial ribosome
- Biology
- Mitochondrial DNA
- Ribosome
- Cell biology
- Molecular biology
- Gene