ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
Brigham and Women's Hospital · Harvard University · +1 more institution
Indexed incrossrefpubmed
Abstract
Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if this contributes to the neuropathic pain-like behavior generated in this model. An L5 SNL induces an immediate (
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Authors
4Topics & keywords
Topics
Keywords
- Neuropathic pain
- Microglia
- MAPK/ERK pathway
- Spinal cord
- Medicine
- Neuroscience
- Protein kinase A
- Astrocyte
UN Sustainable Development Goals
- Good health and well-being
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