Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation
Helmholtz Zentrum München · Medizinische Hochschule Hannover · +4 more institutions
Abstract
Environmental factors such as tobacco smoking may have long-lasting effects on DNA methylation patterns, which might lead to changes in gene expression and in a broader context to the development or progression of various diseases. We conducted an epigenome-wide association study (EWAs) comparing current, former and never smokers from 1793 participants of the population-based KORA F4 panel, with replication in 479 participants from the KORA F3 panel, carried out by the 450K BeadChip with genomic DNA obtained from whole blood. We observed wide-spread differences in the degree of site-specific methylation (with p-values ranging from 9.31E-08 to 2.54E-182) as a function of tobacco smoking in each of the 22…
Citation impact
- FWCI
- 30.66
- Percentile
- 100%
- References
- 52
Authors
13- SZSonja Zeilinger
Helmholtz Zentrum München
- BKBrigitte Kühnel
Helmholtz Zentrum München
- NKNorman Klopp
Medizinische Hochschule Hannover, Helmholtz Zentrum München
- HBHansjörg Baurecht
Technical University of Munich, University of Lübeck, University Hospital Schleswig-Holstein
- AKAnja Kleinschmidt
Helmholtz Zentrum München
Topics & keywords
- DNA methylation
- Methylation
- Genetics
- Context (archaeology)
- Epigenetics
- Biology
- Epigenome
- Tobacco smoke
- Good health and well-being