Extracellular Matrix Degradation and Remodeling in Development and Disease
University of Manchester · Cancer Research UK Manchester Institute · +2 more institutions
Abstract
The extracellular matrix (ECM) serves diverse functions and is a major component of the cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a remodeling process where ECM components are deposited, degraded, or otherwise modified. ECM dynamics are indispensible during restructuring of tissue architecture. ECM remodeling is an important mechanism whereby cell differentiation can be regulated, including processes such as the establishment and maintenance of stem cell niches, branching morphogenesis, angiogenesis, bone remodeling, and wound repair. In contrast, abnormal ECM dynamics lead to deregulated cell proliferation and invasion, failure of cell death, and loss of cell…
Citation impact
- FWCI
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- Percentile
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- References
- 132
Authors
4- PLPengfei LuCorresponding
University of Manchester, Cancer Research UK Manchester Institute, Wellcome Centre for Cell-Matrix Research, University of California, San Francisco
- KTKen Takai
University of California, San Francisco
- VMValerie M. Weaver
University of California, San Francisco
- ZWZena Werb
University of California, San Francisco
Topics & keywords
- Biology
- Library science
- Extracellular matrix
- Regeneration (biology)
- Stem cell biology
- Gerontology
- Computer science
- Genetics
- Good health and well-being