Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
Johns Hopkins University · Johns Hopkins Medicine · +7 more institutions
Abstract
Apoptosis-inducing factor (AIF), a mitochondrial oxidoreductase, is released into the cytoplasm to induce cell death in response to poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation. How PARP-1 activation leads to AIF release is not known. Here we identify PAR polymer as a cell death signal that induces release of AIF. PAR polymer induces mitochondrial AIF release and translocation to the nucleus. PAR glycohydrolase, which degrades PAR polymer, prevents PARP-1-dependent AIF release. Cells with reduced levels of AIF are resistant to PARP-1-dependent cell death and PAR polymer cytotoxicity. These results reveal PAR polymer as an AIF-releasing factor that plays important roles in PARP-1-dependent cell…
Citation impact
- FWCI
- 18.56
- Percentile
- 100%
- References
- 30
Authors
7- SYSeong-Woon YuCorresponding
Johns Hopkins University, Johns Hopkins Medicine, Institute of Pathology Celle, Neurology, Inc
- SAShaida A. Andrabi
Johns Hopkins University, Johns Hopkins Medicine, Institute of Pathology Celle, Neurology, Inc
- HWHongmin Wang
University of Maryland, Baltimore, Johns Hopkins University, Institute of Pathology Celle, Neurology, Inc, University of Baltimore
- NSNo Soo Kim
Johns Hopkins University, Institute of Pathology Celle, Neurology, Inc
- GGGuy G. Poirier
Centre hospitalier universitaire de Québec, Université Laval
Topics & keywords
- Apoptosis-inducing factor
- Poly ADP ribose polymerase
- Programmed cell death
- Apoptosis
- Cytoplasm
- Cell biology
- Mitochondrion
- Biology
- Good health and well-being