IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
Massachusetts General Hospital · Shiga University of Medical Science · +2 more institutions
Abstract
Expression of IL-22 is induced in several human inflammatory conditions, including inflammatory bowel disease (IBD). Expression of the IL-22 receptor is restricted to innate immune cells; however, the role of IL-22 in colitis has not yet been defined. We developed what we believe to be a novel microinjection-based local gene-delivery system that is capable of targeting the inflamed intestine. Using this approach, we demonstrated a therapeutic potency for IL-22-mediated activation of the innate immune pathway in a mouse model of Th2-mediated colitis that induces disease with characteristics similar to that of IBD ulcerative colitis (UC). IL-22 gene delivery enhanced STAT3 activation specifically within colonic…
Citation impact
- FWCI
- 36.89
- Percentile
- 100%
- References
- 62
Authors
9Topics & keywords
- Ulcerative colitis
- Colitis
- Inflammatory bowel disease
- Immunology
- Inflammation
- Mucus
- Innate immune system
- Immune system
- Good health and well-being