Enantio- and Diastereodivergent Dual Catalysis: α-Allylation of Branched Aldehydes

Independent Chiral Catalysts Synthetic catalysts can be prepared in their mirror-image form and thereby furnish the mirror-image (enantiomer) of the reaction product. In practice, however, this versatility is largely limited to products featuring a single stereocenter that accounts for the dissymmetry. Krautwald et al. (p. 1065 ; see the Perspective by Schindler and Jacobsen ) now report a pair of chiral catalysts—an iridium complex and an amine—that operate in concert to facilitate carbon-carbon bond formation, while retaining independent stereoselectivity toward their respective sides of the bond.