reviewThe American Journal of GastroenterologyApr 24, 2012Closed access

Risk of Clostridium difficile Infection With Acid Suppressing Drugs and Antibiotics: Meta-Analysis

CSChun Shing KwokAKAaron Kobina ArthurCIChukwudubem Ifeanyichukwu AnibuezeSSSonal SinghRCRodrigo Cavallazzi

University of East Anglia · Johns Hopkins University · +2 more institutions

PubMed
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Abstract

Objectives

Several studies have raised concern regarding the possible association between proton-pump inhibitors (PPIs) and Clostridium difficile infection (CDI). We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs).

Methods

We searched MEDLINE and EMBASE from inception to December 2011 for controlled observational studies that reported on the risk of CDI with and without PPI use. We performed random effects meta-analysis and assessed statistical heterogeneity using the I(2) statistic.

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573
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71
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Authors

6

Topics & keywords

Topics
Keywords
  • Medicine
  • Internal medicine
  • Meta-analysis
  • Odds ratio
  • Confidence interval
  • Clostridium difficile
  • Relative risk
  • Cohort study
UN Sustainable Development Goals
  • Good health and well-being
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