The Schistosoma japonicum genome reveals features of host–parasite interplay

Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metazoan pathogen, revealing that it can exploit host nutrients, neuroendocrine hormones and signalling pathways for growth, development and maturation. Having a complex nervous system and a well-developed sensory system, S. japonicum can accept stimulation of the corresponding ligands as a physiological response to different environments, such as fresh water or the tissues of its intermediate and…

• WT
  Wellcome Trust
• NN
  National Natural Science Foundation of China

  Award: 863 Program
• CA
  Chinese Academy of Sciences
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council
• NH
  National High-tech Research and Development Program
• NI
  National Institute of Allergy and Infectious Diseases