UV-Emitting Upconversion-Based TiO 2 Photosensitizing Nanoplatform: Near-Infrared Light Mediated in Vivo Photodynamic Therapy via Mitochondria-Involved Apoptosis Pathway
Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · +1 more institution
Abstract
Photodynamic therapy (PDT) is a promising antitumor treatment that is based on the photosensitizers that inhibit cancer cells by yielding reactive oxygen species (ROS) after irradiation of light with specific wavelengths. As a potential photosensitizer, titanium dioxide (TiO2) exhibits minimal dark cytotoxicity and excellent ultraviolet (UV) light triggered cytotoxicity, but is challenged by the limited tissue penetration of UV light. Herein, a novel near-infrared (NIR) light activated photosensitizer for PDT based on TiO2-coated upconversion nanoparticle (UCNP) core/shell nanocomposites (UCNPs@TiO2 NCs) is designed. NaYF4:Yb(3+),Tm(3+)@NaGdF4:Yb(3+) core/shell UCNPs can efficiently convert NIR light to UV…
Citation impact
- FWCI
- 35.82
- Percentile
- 100%
- References
- 89
Authors
10- ZHZhiyao HouCorresponding
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- YZYuanxin Zhang
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
- KDKerong Deng
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- YCYinyin Chen
Chinese Academy of Sciences, University of Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- XLXiaojing Li
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Topics & keywords
- Photodynamic therapy
- Photon upconversion
- In vivo
- Apoptosis
- Materials science
- Fluorescence
- Photosensitizer
- Photochemistry