Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

Gold, Marielle C.; Cerri, Stefania; Smyk‐Pearson, Susan; Cansler, Meghan; Vogt, Todd M.; Delepine, Jacob; Winata, Ervina; Swarbrick, Gwendolyn; Chua, Wei‐Jen; Yu, Yik Y. L.; Lantz, Olivier; Cook, Matthew S.; Null, Megan; Jacoby, David B.; Harriff, Melanie J.; Lewinsohn, Deborah A.; Lewinsohn, Deborah A.; Hansen, Ted H.; Lewinsohn, David; Lewinsohn, David

doi:10.1371/journal.pbio.1000407

articlePLoS BiologyJun 29, 2010GOLD OA

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

MCMarielle C. Gold SCStefania Cerri SSSusan Smyk‐Pearson MCMeghan Cansler TMTodd M. Vogt

Oregon Health & Science University · Portland VA Medical Center · +3 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution analysis that nonclassically restricted CD8+ T cells are universally present, but predominate in Mtb-uninfected individuals. Interestingly, these Mtb-reactive cells expressed the Valpha7.2 T-cell receptor (TCR), were restricted by the nonclassical MHC (HLA-Ib) molecule MR1, and were activated in a transporter associated with antigen processing and presentation (TAP) independent manner. These properties are all characteristics of mucosal associated invariant T…

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674

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FWCI: 9.23
Percentile: 100%
References: 52

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Topics & keywords

Topics

Keywords

Biology
Immunology
Cytotoxic T cell
T-cell receptor
Natural killer T cell
CD8
T cell
Peripheral blood mononuclear cell

UN Sustainable Development Goals

Good health and well-being

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