Pharmaceutical Cocrystallization:  Engineering a Remedy for Caffeine Hydration

A systematic crystal engineering study was performed on the model pharmaceutical compound caffeine to prepare a cocrystal that, unlike caffeine, is physically stable at all relative humidities (RH). Six cocrystal materials containing caffeine with one of several dicarboxylic acids are described herein. Methods of cocrystallization included solution growth, neat solid-state grinding, and grinding with solvent-drop addition. Crystal structures are reported for a total of five cocrystals containing caffeine (with oxalic acid, malonic acid, maleic acid, and glutaric acid), including two recently reported polymorphic caffeine cocrystals. In each of these structures, a predicted intermolecular hydrogen-bonding motif…