A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy
Oslo University Hospital · University of Oslo · +5 more institutions
Abstract
PURPOSE: Hans and coworkers previously developed an immunohistochemical algorithm with approximately 80% concordance with the gene expression profiling (GEP) classification of diffuse large B-cell lymphoma (DLBCL) into the germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subtypes. Since then, new antibodies specific to germinal center B-cells have been developed, which might improve the performance of an immunostain algorithm. EXPERIMENTAL DESIGN: We studied 84 cases of cyclophosphamide-doxorubicin-vincristine-prednisone (CHOP)-treated DLBCL (47 GCB, 37 ABC) with GCET1, CD10, BCL6, MUM1, FOXP1, BCL2, MTA3, and cyclin D2 immunostains, and compared different combinations of the immunostaining…
Citation impact
- FWCI
- 28.72
- Percentile
- 100%
- References
- 49
Authors
25- WWWilliam W.L. ChoiCorresponding
Oslo University Hospital, University of Oslo, John Radcliffe Hospital, University of Oxford, University of Nebraska Medical Center
- DDDennis D. Weisenburger
Oslo University Hospital, University of Oslo, John Radcliffe Hospital, University of Oxford, University of Nebraska Medical Center
- TCTimothy C. Greiner
Oslo University Hospital, University of Oslo, John Radcliffe Hospital, University of Oxford, University of Nebraska Medical Center
- MÁMiguel Á. Piris
Oslo University Hospital, University of Oslo, Instituto de Salud Carlos III, John Radcliffe Hospital, University of Oxford, University of Nebraska Medical Center
- AHAlison H. Banham
Oslo University Hospital, University of Oslo, John Radcliffe Hospital, University of Oxford, University of Nebraska Medical Center
Topics & keywords
- BCL6
- Diffuse large B-cell lymphoma
- Algorithm
- Immunostaining
- Rituximab
- Germinal center
- Lymphoma
- Vincristine