Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
University of Vermont · Sanquin · +2 more institutions
Abstract
The inhalation of airborne pollutants, such as asbestos or silica, is linked to inflammation of the lung, fibrosis, and lung cancer. How the presence of pathogenic dust is recognized and how chronic inflammatory diseases are triggered are poorly understood. Here, we show that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1beta secretion. Inflammasome activation is triggered by reactive oxygen species, which are generated by a NADPH oxidase upon particle phagocytosis. (NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate.) In a model of asbestos inhalation, Nalp3-/- mice showed diminished recruitment of inflammatory cells to the…
Citation impact
- FWCI
- 66.39
- Percentile
- 100%
- References
- 27
Authors
6- CDCatherine DostertCorresponding
University of Vermont, Sanquin, University of Alabama at Birmingham, University of Lausanne
- VPVirginie Pétrilli
University of Vermont, Sanquin, University of Alabama at Birmingham, University of Lausanne
- RVRobin van Bruggen
University of Vermont, Sanquin, University of Alabama at Birmingham, University of Lausanne
- CSChad Steele
University of Vermont, Sanquin, University of Alabama at Birmingham, University of Lausanne
- BTBrooke T. Mossman
University of Vermont, Sanquin, University of Alabama at Birmingham, University of Lausanne
Topics & keywords
- Inflammasome
- NALP3
- Proinflammatory cytokine
- Nicotinamide adenine dinucleotide phosphate
- Inflammation
- Chemistry
- Asbestos
- Reactive oxygen species