Cardiac Troponin T Measured by a Highly Sensitive Assay Predicts Coronary Heart Disease, Heart Failure, and Mortality in the Atherosclerosis Risk in Communities Study
University of North Carolina at Chapel Hill · Houston Methodist · +7 more institutions
Abstract
BACKGROUND: We evaluated whether cardiac troponin T (cTnT) measured with a new highly sensitive assay was associated with incident coronary heart disease (CHD), mortality, and hospitalization for heart failure (HF) in a general population of participants in the Atherosclerosis Risk in Communities (ARIC) Study. METHODS AND RESULTS: Associations between increasing cTnT levels and CHD, mortality, and HF hospitalization were evaluated with Cox proportional hazards models adjusted for traditional CHD risk factors, kidney function, high-sensitivity C-reactive protein, and N-terminal pro-B-type natriuretic peptide in 9698 participants aged 54 to 74 years who at baseline were free from CHD and stroke (and HF in the HF…
Citation impact
- FWCI
- 40.58
- Percentile
- 100%
- References
- 31
Authors
14- JTJustin T. SaundersCorresponding
University of North Carolina at Chapel Hill, Houston Methodist, Michael E. DeBakey VA Medical Center, University of Minnesota, Johns Hopkins University, University of Mississippi Medical Center, Minnesota Department of Health, The University of Texas Southwestern Medical Center, The University of Texas Health Science Center at Houston
- VNVijay Nambi
University of North Carolina at Chapel Hill, Houston Methodist, Michael E. DeBakey VA Medical Center, University of Minnesota, Johns Hopkins University, University of Mississippi Medical Center, Minnesota Department of Health, The University of Texas Southwestern Medical Center, The University of Texas Health Science Center at Houston
- JAJames A. de Lemos
University of North Carolina at Chapel Hill, Houston Methodist, Michael E. DeBakey VA Medical Center, University of Minnesota, Johns Hopkins University, University of Mississippi Medical Center, Minnesota Department of Health, The University of Texas Southwestern Medical Center, The University of Texas Health Science Center at Houston
- LELloyd E. Chambless
University of North Carolina at Chapel Hill, Houston Methodist, Michael E. DeBakey VA Medical Center, University of Minnesota, Johns Hopkins University, University of Mississippi Medical Center, Minnesota Department of Health, The University of Texas Southwestern Medical Center, The University of Texas Health Science Center at Houston
- SSSalim S. Virani
University of North Carolina at Chapel Hill, Houston Methodist, Michael E. DeBakey VA Medical Center, University of Minnesota, Johns Hopkins University, University of Mississippi Medical Center, Minnesota Department of Health, The University of Texas Southwestern Medical Center, The University of Texas Health Science Center at Houston
Topics & keywords
- Medicine
- Hazard ratio
- Internal medicine
- Cardiology
- Confidence interval
- Heart failure
- Natriuretic peptide
- Proportional hazards model
- Good health and well-being