Sex differences in the structural connectome of the human brain

Ingalhalikar, Madhura; Smith, Alexander C.W.; Parker, Drew; Satterthwaite, Theodore D.; Elliott, Mark A.; Ruparel, Kosha; Håkonarson, Håkon; Gur, Raquel E.; Gur, Ruben C.; Verma, Ragini

doi:10.1073/pnas.1316909110

articleProceedings of the National Academy of SciencesDec 2, 2013BRONZE OA

Sex differences in the structural connectome of the human brain

MIMadhura Ingalhalikar ACAlexander C.W. Smith DPDrew Parker TDTheodore D. Satterthwaite MAMark A. Elliott

Laboratoire d’Imagerie Biomédicale · University of Pennsylvania · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Sex differences in human behavior show adaptive complementarity: Males have better motor and spatial abilities, whereas females have superior memory and social cognition skills. Studies also show sex differences in human brains but do not explain this complementarity. In this work, we modeled the structural connectome using diffusion tensor imaging in a sample of 949 youths (aged 8-22 y, 428 males and 521 females) and discovered unique sex differences in brain connectivity during the course of development. Connection-wise statistical analysis, as well as analysis of regional and global network measures, presented a comprehensive description of network characteristics. In all supratentorial regions, males had…

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Topics

Keywords

Connectome
Psychology
Human Connectome Project
Mammalian brain
Population
Human brain
Neuroscience
Biology

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