articleInternational Journal of Cell BiologyJan 1, 2010GOLD OA

Cellular Stress Responses: Cell Survival and Cell Death

SFSimone FuldaAMAdrienne M. GormanOHOsamu HoriASAfshin Samali

University Hospital Ulm · Ollscoil na Gaillimhe – University of Galway · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology…

Citation impact

1,516
total citations
FWCI
16.92
Percentile
100%
References
328
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Pyroptosis
  • Programmed cell death
  • Autophagy
  • Context (archaeology)
  • Apoptosis
  • Cell
  • Medicine
  • Cellular stress response
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding