Preterm labor: One syndrome, many causes
National Institutes of Health · University of Michigan · +5 more institutions
Abstract
Preterm birth is associated with 5 to 18% of pregnancies and is a leading cause of infant morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple pathologic processes, leads to 70% of preterm births. The prevention and the treatment of preterm labor have been long-standing challenges. We summarize the current understanding of the mechanisms of disease implicated in this condition and review advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance. The success of progestogen treatment to prevent preterm birth in a subset of patients at risk is a cause for optimism. Solving the mystery of preterm labor, which compromises the health of…
Citation impact
- FWCI
- 83.89
- Percentile
- 100%
- References
- 73
Authors
3- RRRoberto RomeroCorresponding
National Institutes of Health, University of Michigan, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Michigan State University
- SKSudhansu K. Dey
Cincinnati Children's Hospital Medical Center, Perinatal Institute
- SJSusan J. Fisher
Reproductive Science Center
Topics & keywords
- Preterm labor
- Medicine
- Optimism
- Disease
- Pregnancy
- Premature birth
- Premature labor
- Obstetrics
Funding
- UDU.S. Department of Health and Human Services
- MOMarch of Dimes Foundation
- NINational Institutes of HealthAwards: DA06668, HD068524, R37 HD076253, U54 HD055764
- NINational Institute of Child Health and Human DevelopmentAward: HD068524
- EKEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentAwards: HD055764, HD068524, R37 HD076253
- NDNHLBI Division of Intramural Research