Natural selection shaped regional mtDNA variation in humans
Emory University · Cornell University · +1 more institution
Abstract
Human mtDNA shows striking regional variation, traditionally attributed to genetic drift. However, it is not easy to account for the fact that only two mtDNA lineages (M and N) left Africa to colonize Eurasia and that lineages A, C, D, and G show a 5-fold enrichment from central Asia to Siberia. As an alternative to drift, natural selection might have enriched for certain mtDNA lineages as people migrated north into colder climates. To test this hypothesis we analyzed 104 complete mtDNA sequences from all global regions and lineages. African mtDNA variation did not significantly deviate from the standard neutral model, but European, Asian, and Siberian plus Native American variations did. Analysis of amino…
Citation impact
- FWCI
- 14.26
- Percentile
- 100%
- References
- 38
Authors
13- DMDan Mishmar
Emory University, Cornell University
- EREduardo Ruiz‐Pesini
Emory University, Cornell University, Wellcome Centre for Mitochondrial Research
- PGPaweł Golik
Emory University, Cornell University, Wellcome Centre for Mitochondrial Research
- VMVincent Macaulay
Emory University, Cornell University
- AGAndrew G. Clark
Emory University, Cornell University
Topics & keywords
- Nonsynonymous substitution
- Mitochondrial DNA
- Biology
- Genetics
- Natural selection
- Gene
- Negative selection
- Genetic variation
- Climate action