Non-coding RNAs as regulators of gene expression and epigenetics
University of California, San Diego · University of Eastern Finland · +1 more institution
Abstract
Genome-wide studies have revealed that mammalian genomes are pervasively transcribed. This has led to the identification and isolation of novel classes of non-coding RNAs (ncRNAs) that influence gene expression by a variety of mechanisms. Here we review the characteristics and functions of regulatory ncRNAs in chromatin remodelling and at multiple levels of transcriptional and post-transcriptional regulation. We also describe the potential roles of ncRNAs in vascular biology and in mediating epigenetic modifications that might play roles in cardiovascular disease susceptibility. The emerging recognition of the diverse functions of ncRNAs in regulation of gene expression suggests that they may represent new…
Citation impact
- FWCI
- 11.13
- Percentile
- 100%
- References
- 147
Authors
3Topics & keywords
- Epigenetics
- Biology
- microRNA
- Regulation of gene expression
- Gene
- Chromatin
- Gene expression
- Computational biology
- Good health and well-being
Funding
- FFFoundation for Cardiovascular Research
- FLFondation Leducq
- SKSuomen Kulttuurirahasto
- SSydäntutkimussäätiö
- OTOrionin Tutkimussäätiö
- NINational Institutes of HealthAwards: T32 GM008666, GM007198, T32 GM007198, GM008666
- UOUniversity of California, San DiegoAward: T32 GM008666
- NINational Institute of General Medical SciencesAwards: GM008666, T32 GM007198, T32 GM008666, GM007198