articleJournal of the American Chemical SocietyMar 12, 2014HYBRID OA

Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore

ZZZhiwei ZuoDWDavid W. C. MacMillan

Princeton University

PubMed
Indexed incrossrefpubmed

Abstract

The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.

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555
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2

Topics & keywords

Topics
Keywords
  • Chemistry
  • Photoredox catalysis
  • Pharmacophore
  • Amino acid
  • Catalysis
  • Amine gas treating
  • Substrate (aquarium)
  • Combinatorial chemistry
UN Sustainable Development Goals
  • Clean water and sanitation
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