Self-assembled hydrogels utilizing polymer–nanoparticle interactions

Mouldable hydrogels that flow on applied stress and rapidly self-heal are increasingly utilized as they afford minimally invasive delivery and conformal application. Here we report a new paradigm for the fabrication of self-assembled hydrogels with shear-thinning and self-healing properties employing rationally engineered polymer–nanoparticle (NP) interactions. Biopolymer derivatives are linked together by selective adsorption to NPs. The transient and reversible interactions between biopolymers and NPs enable flow under applied shear stress, followed by rapid self-healing when the stress is relaxed. We develop a physical description of polymer–NP gel formation that is utilized to design biocompatible gels for…

• UD
  U.S. Department of Defense

  Awards: W81XWH, W81XWH-13-1-0215, W81XWH-13
• WT
  Wellcome Trust
• NI
  National Institutes of Health

  Awards: R01 DE016516, NIH-R01, W81XWH, DE016516
• CD
  Congressionally Directed Medical Research Programs