reviewAntioxidants and Redox SignalingJul 15, 2012HYBRID OA

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

DDDaniele Del RioARAna Rodriguez‐MateosJPJeremy P. E. SpencerMTMassimiliano TognoliniGBGina Borges

University of Parma · University of Reading · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Human intervention trials have provided evidence for protective effects of various (poly)phenol-rich foods against chronic disease, including cardiovascular disease, neurodegeneration, and cancer. While there are considerable data suggesting benefits of (poly)phenol intake, conclusions regarding their preventive potential remain unresolved due to several limitations in existing studies. Bioactivity investigations using cell lines have made an extensive use of both (poly)phenolic aglycones and sugar conjugates, these being the typical forms that exist in planta, at concentrations in the low-μM-to-mM range. However, after ingestion, dietary (poly)phenolics appear in the circulatory system not as the parent…

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Topics & keywords

Topics
Keywords
  • Bioavailability
  • Ingestion
  • Pharmacology
  • Human health
  • Gastrointestinal tract
  • Chemistry
  • In vivo
  • In vitro
UN Sustainable Development Goals
  • Good health and well-being
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