Randomized, Controlled Trial of Ultrasound-Assisted Catheter-Directed Thrombolysis for Acute Intermediate-Risk Pulmonary Embolism
Heidelberg University · University Hospital Heidelberg · +6 more institutions
Abstract
BACKGROUND: In patients with acute pulmonary embolism, systemic thrombolysis improves right ventricular (RV) dilatation, is associated with major bleeding, and is withheld in many patients at risk. This multicenter randomized, controlled trial investigated whether ultrasound-assisted catheter-directed thrombolysis (USAT) is superior to anticoagulation alone in the reversal of RV dilatation in intermediate-risk patients. METHODS AND RESULTS: Fifty-nine patients (63±14 years) with acute main or lower lobe pulmonary embolism and echocardiographic RV to left ventricular dimension (RV/LV) ratio ≥1.0 were randomized to receive unfractionated heparin and an USAT regimen of 10 to 20 mg recombinant tissue plasminogen…
Citation impact
- FWCI
- 39.91
- Percentile
- 100%
- References
- 23
Authors
19- NKNils KucherCorresponding
Heidelberg University, University Hospital Heidelberg, Universität Greifswald, Helios Hospital Siegburg, Klinikum Dortmund, Klinikum Lippe, University Hospital Carl Gustav Carus, Ludwig-Maximilians-Universität München
- PBPeter Boekstegers
Heidelberg University, University Hospital Heidelberg, Universität Greifswald, Klinikum Dortmund, Klinikum Lippe, Ludwig-Maximilians-Universität München
- OJOliver J. Müller
Heidelberg University, University Hospital Heidelberg, Universität Greifswald, Helios Hospital Siegburg, Klinikum Dortmund, Klinikum Lippe, Ludwig-Maximilians-Universität München
- CKChristian Kupatt
Heidelberg University, University Hospital Heidelberg, Universität Greifswald, Helios Hospital Siegburg, Klinikum Dortmund, Klinikum Lippe, University Hospital Carl Gustav Carus, Ludwig-Maximilians-Universität München
- JBJan Beyer‐Westendorf
Heidelberg University, University Hospital Heidelberg, Universität Greifswald, Helios Hospital Siegburg, Klinikum Dortmund, Klinikum Lippe, University Hospital Carl Gustav Carus, Ludwig-Maximilians-Universität München
Topics & keywords
- Medicine
- Thrombolysis
- Pulmonary embolism
- Heparin
- Internal medicine
- Cardiology
- Randomized controlled trial
- Surgery
- Good health and well-being