MicroRNAs as master regulators of the plant NB-LRR defense gene family via the production of phased, trans -acting siRNAs
Biotechnology Institute · University of Delaware · +4 more institutions
Abstract
Legumes and many nonleguminous plants enter symbiotic interactions with microbes, and it is poorly understood how host plants respond to promote beneficial, symbiotic microbial interactions while suppressing those that are deleterious or pathogenic. Trans-acting siRNAs (tasiRNAs) negatively regulate target transcripts and are characterized by siRNAs spaced in 21-nucleotide (nt) "phased" intervals, a pattern formed by DICER-LIKE 4 (DCL4) processing. A search for phased siRNAs (phasiRNAs) found at least 114 Medicago loci, the majority of which were defense-related NB-LRR-encoding genes. We identified three highly abundant 22-nt microRNA (miRNA) families that target conserved domains in these NB-LRRs and trigger…
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Authors
16- JZJixian ZhaiCorresponding
Biotechnology Institute, University of Delaware
- DJDong‐Hoon Jeong
Biotechnology Institute, University of Delaware
- EDEmanuele De Paoli
Biotechnology Institute, University of Delaware
- SPSunhee Park
Biotechnology Institute, University of Delaware
- BDBenjamin D. Rosen
University of California, Davis
Topics & keywords
- Biology
- Dicer
- Small interfering RNA
- Genetics
- microRNA
- Gene silencing
- RNA interference
- Gene