Intrinsic Disorder in Transcription Factors

Intrinsic disorder (ID) is highly abundant in eukaryotes, which reflect the greater need for disorder-associated signaling and transcriptional regulation in nucleated cells. Although several well-characterized examples of intrinsically disordered proteins in transcriptional regulation have been reported, no systematic analysis has been reported so far. To test for the general prevalence of intrinsic disorder in transcriptional regulation, we used the predictor of natural disorder regions (PONDR) to analyze the abundance of intrinsic disorder in three transcription factor datasets and two control sets. This analysis revealed that from 94.13 to 82.63% of transcription factors possess extended regions of…

• EL
  Eli Lilly and Company
• TU
  Temple University
• NI
  National Institutes of Health

  Award: R01 LM007688-01A1
• RA
  Russian Academy of Sciences

  Award: R01 LM007688-01A1