Tissue-based map of the human proteome

Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32…

• KO
  Knut och Alice Wallenbergs Stiftelse
• SF
  Science for Life Laboratory
• UF
  U.S. Food and Drug Administration
• UM
  Uppsala Multidisciplinary Center for Advanced Computational Science