Apoptosis and cancer: mutations within caspase genes

Ghavami, Saeid; Hashemi, Mohammad; Ande, Sudharsana Rao; Yeganeh, Behzad; Xiao, Wenyan; Eshraghi, Mohsen; Bus, Christine; Kadkhoda, Kamran; Wiecheć, Emilia; Halayko, Andrew J.; Los, M

doi:10.1136/jmg.2009.066944

reviewJournal of Medical GeneticsJun 7, 2009BRONZE OA

Apoptosis and cancer: mutations within caspase genes

SGSaeid Ghavami MHMohammad Hashemi SRSudharsana Rao Ande BYBehzad Yeganeh WXWenyan Xiao

Research Manitoba · Children's Hospital Research Institute of Manitoba · +8 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead to tumorigenesis, autoimmunity, and other serious health problems. Deregulated apoptosis may also be the leading cause of cancer therapy chemoresistance. Caspase family of cysteinyl-proteases plays the key role in the initiation and execution of programmed cell death. This review gives an overview of the role of caspases, their natural modulators like IAPs, FLIPs, and Smac/Diablo in apoptosis and upon inactivation, and also in cancer development. Besides describing the basic mechanisms governing programmed cell…

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707

total citations

FWCI: 15.47
Percentile: 100%
References: 228

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Authors

11

Topics & keywords

Topics

Keywords

XIAP
Caspase
Programmed cell death
Inhibitor of apoptosis
Pyroptosis
Apoptosis
Biology
Proteases

UN Sustainable Development Goals

Good health and well-being

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