Endocytosis and exocytosis of nanoparticles in mammalian cells

Engineered nanoparticles that can be injected into the human body hold tremendous potential to detect and treat complex diseases. Understanding of the endocytosis and exocytosis mechanisms of nanoparticles is essential for safe and efficient therapeutic application. In particular, exocytosis is of significance in the removal of nanoparticles with drugs and contrast agents from the body, while endocytosis is of great importance for the targeting of nanoparticles in disease sites. Here, we review the recent research on the endocytosis and exocytosis of functionalized nanoparticles based on various sizes, shapes, and surface chemistries. We believe that this review contributes to the design of safe nanoparticles…

• NR
  National Research Foundation
• MO
  Ministry of Science, ICT and Future Planning
• NR
  National Research Foundation of Korea
• MO
  Ministry of Education, Science and Technology

  Award: R32-2008-000-10218-0