The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology
National Institute of Mental Health · National Institute of Mental Health · +2 more institutions
Abstract
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.
Citation impact
- FWCI
- 10.40
- Percentile
- 100%
- References
- 27
Authors
9- LPLukas PezawasCorresponding
National Institute of Mental Health, National Institute of Mental Health, National Institute of Mental Health
- BABeth A. Verchinski
National Institutes of Health
- VSVenkata S. Mattay
National Institutes of Health
- JHJoseph H. Callicott
National Institutes of Health
- BKBhaskar Kolachana
National Institutes of Health
Topics & keywords
- Brain morphometry
- Neuroscience
- Neurotrophic factors
- Hippocampus
- Human brain
- Psychology
- Functional magnetic resonance imaging
- Brain-derived neurotrophic factor