Synthetic fluorescent probes for studying copper in biological systems
Berkeley College · University of California System · +2 more institutions
Abstract
The potent redox activity of copper is required for sustaining life. Mismanagement of its cellular pools, however, can result in oxidative stress and damage connected to aging, neurodegenerative diseases, and metabolic disorders. Therefore, copper homeostasis is tightly regulated by cells and tissues. Whereas copper and other transition metal ions are commonly thought of as static cofactors buried within protein active sites, emerging data points to the presence of additional loosely bound, labile pools that can participate in dynamic signalling pathways. Against this backdrop, we review advances in sensing labile copper pools and understanding their functions using synthetic fluorescent indicators. Following…
Citation impact
- FWCI
- 28.84
- Percentile
- 100%
- References
- 145
Authors
4- JAJoseph A. Cotruvo
Berkeley College, University of California System, University of California, Berkeley
- ATAllegra T. Aron
Berkeley College, University of California System, University of California, Berkeley
- KMKarla M. Ramos‐Torres
Berkeley College, University of California System, University of California, Berkeley
- CJChristopher J. ChangCorresponding
Howard Hughes Medical Institute, Berkeley College, University of California System, University of California, Berkeley
Topics & keywords
- Context (archaeology)
- Copper
- Fluorescence
- Chemistry
- Cofactor
- Nanotechnology
- Redox
- Computational biology