The use of gold nanoparticles in diagnostics and detection

The widespread use of gold nanoparticles (GNPs) as labels in diagnostics and detection is due to a unique combination of chemical and physical properties that allow biological molecules to be detected at low concentrations. In this critical review detection methods based on GNPs are divided up and discussed based on the way in which signals are generated in response to specific target molecules. Particular attention is devoted to methods that allow target molecules to be detected with the unaided eye because these, more than any other, harness the full range of properties that make GNPs unique. Methods that are discussed include those in which specific target molecules induce a visible colour change,…