Requirement of bic/microRNA-155 for Normal Immune Function
Babraham Institute · University of Cambridge · +3 more institutions
Abstract
MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155…
Citation impact
- FWCI
- 52.74
- Percentile
- 100%
- References
- 29
Authors
16- ARAntony RodriguezCorresponding
Babraham Institute, University of Cambridge, The Gurdon Institute, Wellcome Sanger Institute, Addenbrooke's Hospital
- EVElena Vigorito
Babraham Institute, University of Cambridge, The Gurdon Institute, Wellcome Sanger Institute, Addenbrooke's Hospital
- SCSimon Clare
Babraham Institute, University of Cambridge, The Gurdon Institute, Wellcome Sanger Institute, Addenbrooke's Hospital
- MWMadhuri Warren
Babraham Institute, University of Cambridge, The Gurdon Institute, Wellcome Sanger Institute, Addenbrooke's Hospital
- PCPhilippe Couttet
Babraham Institute, University of Cambridge, The Gurdon Institute, Wellcome Sanger Institute, Addenbrooke's Hospital
Topics & keywords
- microRNA
- Biology
- Immune system
- Gene
- Transcriptome
- miR-155
- Function (biology)
- Chemokine