reviewActa Pharmaceutica Sinica BDec 5, 2013DIAMOND OA

Fundamental aspects of solid dispersion technology for poorly soluble drugs

YHYanbin HuangWDWeiguo Dai

Tsinghua University · Janssen (United States) · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug-polymer two-component system, the drug-polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology.

Citation impact

583
total citations
FWCI
11.02
Percentile
100%
References
58
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Dispersion (optics)
  • Computer science
  • Medicine
  • Chemistry
  • Physics
  • Optics
UN Sustainable Development Goals
  • Clean water and sanitation
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