The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication
Population Health Research Institute · McMaster University · +2 more institutions
Abstract
BACKGROUND: The probiotic Bifidobacterium longum NCC3001 normalizes anxiety-like behavior and hippocampal brain derived neurotrophic factor (BDNF) in mice with infectious colitis. Using a model of chemical colitis we test whether the anxiolytic effect of B. longum involves vagal integrity, and changes in neural cell function. Methods Mice received dextran sodium sulfate (DSS, 3%) in drinking water during three 1-week cycles. Bifidobacterium longum or placebo were gavaged daily during the last cycle. Some mice underwent subdiaphragmatic vagotomy. Behavior was assessed by step-down test, inflammation by myeloperoxidase (MPO) activity and histology. BDNF mRNA was measured in neuroblastoma SH-SY5Y cells after…
Citation impact
- FWCI
- 11.97
- Percentile
- 100%
- References
- 27
Authors
17- PBPřemysl BerčíkCorresponding
Population Health Research Institute, McMaster University
- AJA. J. Park
Population Health Research Institute, McMaster University
- DSD. Sinclair
Population Health Research Institute, McMaster University
- AKAmir Khoshdel
Population Health Research Institute, McMaster University
- JLJun Lü
Population Health Research Institute, McMaster University
Topics & keywords
- Bifidobacterium longum
- Enteric nervous system
- Anxiolytic
- Vagus nerve
- Hyperalgesia
- Medicine
- Colitis
- Endocrinology
- Clean water and sanitation