reviewJournal of Clinical InvestigationMar 1, 2006BRONZE OA

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

BNBrian N. Finck

Washington University in St. Louis

PubMed
Indexed incrossrefdoajpubmed

Abstract

Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.

Citation impact

1,421
total citations
FWCI
38.48
Percentile
100%
References
93
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • Coactivator
  • Nuclear receptor
  • PPARGC1A
  • Transcription factor
  • Nuclear receptor coactivator 3
  • Cell biology
  • Biology
  • Nuclear receptor coactivator 1
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding