A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs
University of Southern California · University of California, Los Angeles · +3 more institutions
Abstract
The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a selective sweep spanning a single gene (IGF1), encoding insulin-like growth factor 1. A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting…
Citation impact
- FWCI
- 28.54
- Percentile
- 100%
- References
- 27
Authors
21- NBNathan B. Sutter
University of Southern California, University of California, Los Angeles, Cornell University, University of Utah, National Human Genome Research Institute
- CDCarlos D. Bustamante
University of Southern California, University of California, Los Angeles, Cornell University, University of Utah, National Human Genome Research Institute
- KCKevin Chase
University of Southern California, University of California, Los Angeles, Cornell University, University of Utah, National Human Genome Research Institute
- MGMelissa Gray
University of Southern California, University of California, Los Angeles, Cornell University, University of Utah, National Human Genome Research Institute
- KZKeyan Zhao
University of Southern California, University of California, Los Angeles, Cornell University, University of Utah, National Human Genome Research Institute
Topics & keywords
- Biology
- Quantitative trait locus
- Breed
- Single-nucleotide polymorphism
- Genetics
- Haplotype
- Allele
- Locus (genetics)