Apolipoprotein-mediated Transport of Nanoparticle-bound Drugs Across the Blood-Brain Barrier

Kreuter, Jörg; Shamenkov, D. A.; Петров, В Е; Ramge, Peter; Cychutek, Klaus; Koch-Brandt, Claudia; Alyautdin, R. N.

doi:10.1080/10611860290031877

articleJournal of drug targetingJan 1, 2002Closed access

Apolipoprotein-mediated Transport of Nanoparticle-bound Drugs Across the Blood-Brain Barrier

JKJörg Kreuter DAD. A. Shamenkov ВЕВ Е Петров PRPeter Ramge KCKlaus Cychutek

Goethe University Frankfurt · Institute of Pharmacology Russian Academy of Medical Sciences · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Recent studies have shown that drugs that are normally unable to cross the blood-brain barrier (BBB) following intravenous injection can be transported across this barrier by binding to poly(butyl cyanoacrylate) nanoparticles and coating with polysorbate 80. However, the mechanism of this transport so far was not known. In the present paper, the possible involvement of apolipoproteins in the transport of nanoparticle-bound drugs into the brain is investigated. Poly(butyl cyanoacrylate) nanoparticles loaded with the hexapeptide dalargin were coated with the apolipoproteins AII, B, CII, E, or J without or after precoating with polysorbate 80. In addition, loperamide-loaded nanoparticles were coated with…

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Topics & keywords

Topics

Keywords

Chemistry
Polysorbate
Polyvinyl alcohol
Apolipoprotein B
Nanoparticle
Blood–brain barrier
Drug delivery to the brain
Pharmacology

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