Alterations in Memory Networks in Mild Cognitive Impairment and Alzheimer's Disease: An Independent Component Analysis
Brigham and Women's Hospital · Hartford Hospital · +7 more institutions
Abstract
Memory function is likely subserved by multiple distributed neural networks, which are disrupted by the pathophysiological process of Alzheimer's disease (AD). In this study, we used multivariate analytic techniques to investigate memory-related functional magnetic resonance imaging (fMRI) activity in 52 individuals across the continuum of normal aging, mild cognitive impairment (MCI), and mild AD. Independent component analyses revealed specific memory-related networks that activated or deactivated during an associative memory paradigm. Across all subjects, hippocampal activation and parietal deactivation demonstrated a strong reciprocal relationship. Furthermore, we found evidence of a nonlinear trajectory…
Citation impact
- FWCI
- 13.05
- Percentile
- 100%
- References
- 49
Authors
12- KCKim CeloneCorresponding
Brigham and Women's Hospital
- VDVince D. Calhoun
Hartford Hospital, Yale University
- BCBradford C. Dickerson
Brigham and Women's Hospital, Harvard University, Harvard University Press, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging
- AAAlireza Atri
Harvard University Press, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging
- EFElizabeth F. Chua
Brigham and Women's Hospital, Harvard University, Harvard University Press
Topics & keywords
- Neuroscience
- Psychology
- Functional magnetic resonance imaging
- Memory impairment
- Hippocampal formation
- Episodic memory
- Hippocampus
- Temporal lobe