articleJournal of NeuroscienceAug 13, 2008BRONZE OA

Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

SESuzanne E. HickmanEAElizabeth AllisonJEJoseph El Khoury

Massachusetts General Hospital · Center for Rheumatology · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Early microglial accumulation in Alzheimer's disease (AD) delays disease progression by promoting clearance of beta-amyloid (Abeta) before formation of senile plaques. However, persistent Abeta accumulation despite increasing microglial numbers suggests that the ability of microglia to clear Abeta may decrease with age and progression of AD pathology. To determine the effects of aging and Abeta deposition on microglial ability to clear Abeta, we used quantitative PCR to analyze gene expression in freshly isolated adult microglia from 1.5-, 3-, 8-, and 14-month-old transgenic PS1-APP mice, an established mouse model of AD, and from their nontransgenic littermates. We found that microglia from old PS1-APP mice,…

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Topics & keywords

Topics
Keywords
  • Microglia
  • Proinflammatory cytokine
  • TREM2
  • Genetically modified mouse
  • Tumor necrosis factor alpha
  • Senile plaques
  • Neurodegeneration
  • Cytokine
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