Ethanolic Extract of Propolis (EEP) Enhances the Apoptosis- Inducing Potential of TRAIL in Cancer Cells
Medical University of Silesia · University of Silesia in Katowice
Abstract
Ethanolic extract of propolis (EEP) is one of the richest sources of phenolic acids and flavonoids. EEP and its phenolic compounds have been known for various biological activities including immunopotentiation, chemopreventive and antitumor effects. Tumor necrosis factor related apoptosis inducing ligand (TRAIL) is a naturally occurring anticancer agent that preferentially induces apoptosis in cancer cells and is not toxic toward normal cells. We examined the cytotoxic and apoptotic effect of EEP and phenolic compounds identified in propolis in combination with TRAIL on HeLa cancer cells. HeLa cells were resistant to TRAIL-induced apoptosis. Our study demonstrated that EEP and its components significantly…
Citation impact
- FWCI
- 14.81
- Percentile
- 100%
- References
- 35
Authors
6- ESEwelina Szliszka
Medical University of Silesia, University of Silesia in Katowice
- ZCZenon Czuba
University of Silesia in Katowice, Medical University of Silesia
- MDMaciej Domino
University of Silesia in Katowice, Medical University of Silesia
- BMBogdan Mazur
University of Silesia in Katowice, Medical University of Silesia
- GZGrzegorz Zydowicz
University of Silesia in Katowice, Medical University of Silesia
Topics & keywords
- Propolis
- HeLa
- Apoptosis
- Cytotoxic T cell
- Cancer cell
- Chemistry
- Apigenin
- Cancer
- Good health and well-being