Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines
The Graduate University for Advanced Studies, SOKENDAI · Japan Science and Technology Agency · +3 more institutions
Abstract
Long-term potentiation (LTP) at glutamatergic synapses is considered to underlie learning and memory and is associated with the enlargement of dendritic spines. Because the consolidation of memory and LTP require protein synthesis, it is important to clarify how protein synthesis affects spine enlargement. In rat brain slices, the repetitive pairing of postsynaptic spikes and two-photon uncaging of glutamate at single spines (a spike-timing protocol) produced both immediate and gradual phases of spine enlargement in CA1 pyramidal neurons. The gradual enlargement was strongly dependent on protein synthesis and brain-derived neurotrophic factor (BDNF) action, often associated with spine twitching, and was…
Citation impact
- FWCI
- 18.93
- Percentile
- 100%
- References
- 26
Authors
6- JTJunichi TanakaCorresponding
The Graduate University for Advanced Studies, SOKENDAI, Japan Science and Technology Agency, National Institute for Physiological Sciences, Drexel University, The University of Tokyo
- YHYoshihiro HoriikeCorresponding
The Graduate University for Advanced Studies, SOKENDAI, Japan Science and Technology Agency, National Institute for Physiological Sciences, Drexel University, The University of Tokyo
- MMM Matsuzaki
The Graduate University for Advanced Studies, SOKENDAI, Japan Science and Technology Agency, National Institute for Physiological Sciences, Drexel University, The University of Tokyo
- TMTakashi Miyazaki
The Graduate University for Advanced Studies, SOKENDAI, Japan Science and Technology Agency, National Institute for Physiological Sciences, Drexel University, The University of Tokyo
- GCGraham C. R. Ellis‐Davies
The Graduate University for Advanced Studies, SOKENDAI, Japan Science and Technology Agency, National Institute for Physiological Sciences, Drexel University, The University of Tokyo
Topics & keywords
- Dendritic spine
- Long-term potentiation
- Postsynaptic potential
- Neuroscience
- Synaptic plasticity
- Dendritic filopodia
- SPINE (molecular biology)
- Chemistry