Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
Rush University Medical Center · Johns Hopkins University · +2 more institutions
Abstract
Alzheimer's disease (AD) is an age-related disorder characterized by deposition of amyloid beta-peptide (Abeta) and degeneration of neurons in brain regions such as the hippocampus, resulting in progressive cognitive dysfunction. The pathogenesis of AD is tightly linked to Abeta deposition and oxidative stress, but it remains unclear as to how these factors result in neuronal dysfunction and death. We report alterations in sphingolipid and cholesterol metabolism during normal brain aging and in the brains of AD patients that result in accumulation of long-chain ceramides and cholesterol. Membrane-associated oxidative stress occurs in association with the lipid alterations, and exposure of hippocampal neurons…
Citation impact
- FWCI
- 14.94
- Percentile
- 100%
- References
- 54
Authors
8- RGRoy G. CutlerCorresponding
Rush University Medical Center, Johns Hopkins University, National Institute on Aging
- JKJeremiah Kelly
Rush University Medical Center, Johns Hopkins University, National Institute on Aging
- KSKristin Storie
Rush University Medical Center, Johns Hopkins University, National Institute on Aging
- WAWard A. Pedersen
Rush University Medical Center, Johns Hopkins University, National Institute on Aging
- ATAnita Tammara
Rush University Medical Center, Johns Hopkins University, National Institute on Aging
Topics & keywords
- Ceramide
- Oxidative stress
- Sphingomyelin
- Sphingolipid
- Pathogenesis
- Cholesterol
- Endocrinology
- Alzheimer's disease
- Good health and well-being