Regulation of hypoxia-inducible factor-1α by NF-κB

HIF (hypoxia-inducible factor) is the main transcription factor activated by low oxygen tensions. HIF-1alpha (and other alpha subunits) is tightly controlled mostly at the protein level, through the concerted action of a class of enzymes called PHDs (prolyl hydroxylases) 1, 2 and 3. Most of the knowledge of HIF derives from studies following hypoxic stress; however, HIF-1alpha stabilization is also found in non-hypoxic conditions through an unknown mechanism. In the present study, we demonstrate that NF-kappaB (nuclear factor kappaB) is a direct modulator of HIF-1alpha expression. The HIF-1alpha promoter is responsive to selective NF-kappaB subunits. siRNA (small interfering RNA) studies for individual…

• UO
  University of Dundee

  Award: SC015096
• WT
  Wellcome Trust
• CR
  Cancer Research UK
• RC
  Research Councils UK
• T
  Tenovus
• DF
  Directorate for Biological Sciences
• MR
  Medical Research Council
• BA
  Biotechnology and Biological Sciences Research Council
• UD
  Université de Namur