Rare Variants of IFIH1 , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
University of Cambridge · Enzo Life Sciences (United States) · +2 more institutions
Abstract
Genome-wide association studies (GWASs) are regularly used to map genomic regions contributing to common human diseases, but they often do not identify the precise causative genes and sequence variants. To identify causative type 1 diabetes (T1D) variants, we resequenced exons and splice sites of 10 candidate genes in pools of DNA from 480 patients and 480 controls and tested their disease association in over 30,000 participants. We discovered four rare variants that lowered T1D risk independently of each other (odds ratio = 0.51 to 0.74; P = 1.3 x 10(-3) to 2.1 x 10(-16)) in IFIH1 (interferon induced with helicase C domain 1), a gene located in a region previously associated with T1D by GWASs. These variants…
Citation impact
- FWCI
- 82.06
- Percentile
- 100%
- References
- 25
Authors
5- SNSergey NejentsevCorresponding
University of Cambridge, Enzo Life Sciences (United States), Cambridge Quantum Computing (United Kingdom), Juvenile Diabetes Research Foundation
- NWNeil Walker
University of Cambridge, Enzo Life Sciences (United States), Cambridge Quantum Computing (United Kingdom), Juvenile Diabetes Research Foundation
- DWDavid W. H. Riches
University of Cambridge, Enzo Life Sciences (United States), Cambridge Quantum Computing (United Kingdom), Juvenile Diabetes Research Foundation
- MDMichael D. Miller
University of Cambridge, Enzo Life Sciences (United States), Cambridge Quantum Computing (United Kingdom), Juvenile Diabetes Research Foundation
- JAJohn A. Todd
University of Cambridge, Enzo Life Sciences (United States), Cambridge Quantum Computing (United Kingdom), Juvenile Diabetes Research Foundation
Topics & keywords
- Gene
- Type 2 diabetes
- Genetics
- Diabetes mellitus
- Biology
- Virology
- Endocrinology
- Good health and well-being