articlePLoS ONEJan 26, 2010GOLD OA

Human Ovarian Reserve from Conception to the Menopause

WHWilliam H. WallaceTKTom Kelsey

University of Edinburgh · MRC Centre for Reproductive Health · +1 more institution

PubMed
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Abstract

The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years. The objective of this study is to model the age-related population of NGFs in the human ovary from conception to menopause. Data were taken from eight separate quantitative histological studies (n = 325) in which NGF populations at known ages from seven weeks post conception to 51 years (median 32 years) were calculated. The data set was fitted to 20 peak function models, with the results ranked by obtained r2 correlation coefficient. The highest ranked model was chosen. Our model matches the log-adjusted NGF population from conception to…

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856
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Topics & keywords

Topics
Keywords
  • Menopause
  • Ovary
  • Population
  • Fertility
  • Ovarian reserve
  • Demography
  • Medicine
  • Endocrinology
UN Sustainable Development Goals
  • Good health and well-being
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